dr4pl: Dose Response Data Analysis using the 4 Parameter Logistic (4pl) Model

Models the relationship between dose levels and responses in a pharmacological experiment using the 4 Parameter Logistic model. Traditional packages on dose-response modelling such as 'drc' and 'nplr' often draw errors due to convergence failure especially when data have outliers or non-logistic shapes. This package provides robust estimation methods that are less affected by outliers and other initialization methods that work well for data lacking logistic shapes. We provide the bounds on the parameters of the 4PL model that prevent parameter estimates from diverging or converging to zero and base their justification in a statistical principle. These methods are used as remedies to convergence failure problems. Gadagkar, S. R. and Call, G. B. (2015) <doi:10.1016/j.vascn.2014.08.006> Ritz, C. and Baty, F. and Streibig, J. C. and Gerhard, D. (2015) <doi:10.1371/journal.pone.0146021>.

Version: 2.0.0
Depends: R (≥ 3.1.0)
Imports: ggplot2, Matrix, tensor, Rdpack, generics, rlang, glue
Suggests: drc, devtools, roxygen2, testthat, knitr, rmarkdown, tibble
Published: 2021-08-17
DOI: 10.32614/CRAN.package.dr4pl
Author: Justin T. Landis [aut, cre], Alice Peng [ctb], Hyowon An [aut], Aubrey G. Bailey [aut], Dirk P. Dittmer [aut], James S. Marron [aut]
Maintainer: Justin T. Landis <jtlandis314 at gmail.com>
BugReports: https://bitbucket.org/dittmerlab/dr4pl/issues?status=new&status=open
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
URL: https://bitbucket.org/dittmerlab/dr4pl
NeedsCompilation: no
Materials: README NEWS
In views: Pharmacokinetics
CRAN checks: dr4pl results


Reference manual: dr4pl.pdf
Vignettes: dr4pl derivatives
dr4pl usage examples


Package source: dr4pl_2.0.0.tar.gz
Windows binaries: r-devel: dr4pl_2.0.0.zip, r-release: dr4pl_2.0.0.zip, r-oldrel: dr4pl_2.0.0.zip
macOS binaries: r-release (arm64): dr4pl_2.0.0.tgz, r-oldrel (arm64): dr4pl_2.0.0.tgz, r-release (x86_64): dr4pl_2.0.0.tgz, r-oldrel (x86_64): dr4pl_2.0.0.tgz
Old sources: dr4pl archive


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