POSTm: Phylogeny-Guided OTU-Specific Association Test for Microbiome Data

Implements the Phylogeny-Guided Microbiome OTU-Specific Association Test method, which boosts the testing power by adaptively borrowing information from phylogenetically close OTUs (operational taxonomic units) of the target OTU. This method is built on a kernel machine regression framework and allows for flexible modeling of complex microbiome effects, adjustments for covariates, and can accommodate both continuous and binary outcomes.

Version: 1.4
Depends: methods
Imports: CompQuadForm, ape
Suggests: multtest, rmarkdown, knitr
Published: 2024-04-17
DOI: 10.32614/CRAN.package.POSTm
Author: Caizhi Huang [aut], Jung-Ying Tzeng [aut], Shannon T. Holloway [aut, cre]
Maintainer: Shannon T. Holloway <shannon.t.holloway at>
License: GPL-2
NeedsCompilation: no
Materials: NEWS
CRAN checks: POSTm results


Reference manual: POSTm.pdf
Vignettes: POSTm: $\text{\underline{P}


Package source: POSTm_1.4.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): POSTm_1.4.tgz, r-oldrel (arm64): POSTm_1.4.tgz, r-release (x86_64): POSTm_1.4.tgz, r-oldrel (x86_64): POSTm_1.4.tgz
Old sources: POSTm archive


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