LTFHPlus: Implementation of LT-FH++

Implementation of LT-FH++, an extension of the liability threshold family history (LT-FH) model. LT-FH++ uses a Gibbs sampler for sampling from the truncated multivariate normal distribution and allows for flexible family structures. LT-FH++ was first described in Pedersen, Emil M., et al. (2022) <> as an extension to LT-FH with more flexible family structures, and again as the age-dependent liability threshold (ADuLT) model Pedersen, Emil M., et al. (2023) <> as an alternative to traditional time-to-event genome-wide association studies, where family history was not considered.

Version: 2.1.1
Imports: batchmeans, dplyr, future.apply, future, purrr, Rcpp, rlang, stats, stringr, tibble, tmvtnorm, tidyselect, igraph, xgboost, tidyr
LinkingTo: Rcpp
Suggests: MASS, knitr, rmarkdown, testthat
Published: 2024-02-12
DOI: 10.32614/CRAN.package.LTFHPlus
Author: Emil Michael Pedersen [aut, cre], Florian Privé [aut, ths], Bjarni Jóhann Vilhjálmsson [ths], Esben Agerbo [ths], Jette Steinbach [aut], Lucas Rasmussen [ctb]
Maintainer: Emil Michael Pedersen <emp at>
License: GPL-3
NeedsCompilation: yes
Language: "en-GB"
Materials: README NEWS
CRAN checks: LTFHPlus results


Reference manual: LTFHPlus.pdf


Package source: LTFHPlus_2.1.1.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): LTFHPlus_2.1.1.tgz, r-oldrel (arm64): LTFHPlus_2.1.1.tgz, r-release (x86_64): LTFHPlus_2.1.1.tgz, r-oldrel (x86_64): LTFHPlus_2.1.1.tgz


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