DYNATE: Dynamic Aggregation Testing

A multiple testing procedure aims to find the rare-variant association regions. When variants are rare, the single variant association test approach suffers from low power. To improve testing power, the procedure dynamically and hierarchically aggregates smaller genome regions to larger ones and performs multiple testing for disease associations with a controlled node-level false discovery rate. This method are members of the family of ancillary information assisted recursive testing introduced in Pura, Li, Chan and Xie (2021) <doi:10.48550/arXiv.1906.07757> and Li, Sung and Xie (2021) <doi:10.48550/arXiv.2103.11085>.

Version: 0.1
Depends: R (≥ 3.5.0)
Imports: data.table, tidyverse, Matrix, reshape2, stats, methods, tibble, dplyr
Suggests: knitr, rmarkdown
Published: 2022-10-14
DOI: 10.32614/CRAN.package.DYNATE
Author: Xuechan Li [aut, cre], Jichun Xie [ctb]
Maintainer: Xuechan Li <xuechanli0530 at gmail.com>
License: GPL-3
NeedsCompilation: no
Materials: README
CRAN checks: DYNATE results


Reference manual: DYNATE.pdf
Vignettes: DYNATE


Package source: DYNATE_0.1.tar.gz
Windows binaries: r-devel: DYNATE_0.1.zip, r-release: DYNATE_0.1.zip, r-oldrel: DYNATE_0.1.zip
macOS binaries: r-release (arm64): DYNATE_0.1.tgz, r-oldrel (arm64): DYNATE_0.1.tgz, r-release (x86_64): DYNATE_0.1.tgz, r-oldrel (x86_64): DYNATE_0.1.tgz


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